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Apical thinning: real or artefact?

Nicola J Purser¹, Ian S Armstrong, Heather A Williams

¹Nuclear Medicine Department, Manchester Royal Infirmary, Manchester, UK.

Nuclear Medicine Communications

|March 5, 2008

Summary

This summary is machine-generated.

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Apical thinning in myocardial perfusion SPECT is often an artifact caused by attenuation correction, not reduced heart muscle thickness. This phantom study shows the imaging process, not anatomy, creates the apparent defect.

Area of Science:

Nuclear cardiology
Medical imaging physics

Background:

Apical thinning is a common observation in myocardial perfusion SPECT.
Attenuation correction (AC) processing may exaggerate this phenomenon, leading to misinterpretation.

Purpose of the Study:

To investigate the cause of apparent apical thinning in myocardial perfusion SPECT.
To determine if AC is responsible for the observed apical defects using phantom studies.

Main Methods:

Utilized an anthropomorphic torso phantom with varying sizes.
Images acquired using a dual-headed gamma camera with low-dose CT-based AC.
Data processed with iterative reconstruction, with and without AC.

Main Results:

Apparent apical thinning defects emerged after AC, worsening with phantom size, despite uniform phantom wall thickness.

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Defect severity correlated more with breast activity than attenuation material.

Iterative reconstruction parameter adjustments influenced artifact severity.

Conclusions:

The apparent apical defect in myocardial perfusion SPECT is likely an artifact.
Attenuation correction processing contributes significantly to the appearance of apical thinning, which is not solely an anatomical feature.