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Lipid profile and intensity of atherosclerosis disease in acute coronary syndrome

Rafaela Andrade Penalva1, Marçal de Oliveira Huoya, Luis Cláudio Lemos Correia

  • 1Escola Bahiana de Medicina e Saúde Pública, Hospital Santa Izabel, Salvador, BA, Brasil. rafaelapenalva@yahoo.com.br

Arquivos Brasileiros De Cardiologia
|March 5, 2008
PubMed

Insights

The cholesterol-to-HDL ratio indicates coronary artery disease severity in acute coronary syndrome patients. This lipid profile marker helps determine disease extent, particularly in those without ST-segment elevation.

Area of Science:

  • Cardiology
  • Clinical Lipidology
  • Epidemiology

Background:

  • The link between dyslipidemia and coronary artery disease (CAD) in acute coronary syndromes (ACS) is under-researched.
  • Few studies demonstrate this relationship in clinical and epidemiological contexts.

Purpose of the Study:

  • To assess the association between lipid profiles and CAD severity in ACS patients without ST-segment elevation.
  • To identify lipid markers predictive of CAD extent.

Main Methods:

  • Retrospective analysis of 107 ACS patients without ST-segment elevation undergoing coronary angiography.
  • Evaluation of serum lipid levels and coronary artery obstruction severity (number, degree, score).
  • Statistical analysis including t-test, chi-square, ANOVA, and multivariate analysis (p<0.05).

Main Results:

  • 94% of patients had CAD, with a predominance of multivessel disease (53.2% males).
  • A higher total cholesterol-to-HDL (TC/HDL) ratio was observed in multivessel and two-vessel disease groups compared to one-vessel disease (p=0.049).
  • Multivariate analysis confirmed TC/HDL ratio as a significant predictor of CAD severity (p=0.016).

Conclusions:

  • The TC/HDL ratio serves as a marker for CAD severity, correlating with the number of affected coronary vessels.
  • Lipid profiles, specifically the TC/HDL ratio, can determine disease severity in ACS patients without ST-segment elevation.
Abstract

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