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Glioblastoma multiforme with an abscess: case report and literature review
Ondrej Kalita1, Miroslav Kala, Hana Svebisova
1Neurosurgical Department, University Hospital, Olomouc 77520, Czech Republic. kalitao@email.cz
Abstract:
An intratumoral or peritumoral microbial intracranial abscess is an infrequent diagnosis. The development of this complication may not be preceded by apparent local or general infection in all cases. To identify this diagnosis by radiological (MRI) or laboratory investigations is very intricate. Nevertheless, the recommended life-saving strategy is early surgery with resolution of both the tumor and infection. If subsequent oncological treatment is required, it has to be adjusted for prevention of re-inflammation. The described patient suffered from an intracranial abscess superimposed on a Glioblastoma Multiforme. The confirmed etiological agent was Staphylococcus aureus. The suspected route of microbial migration and colonization in this tumor was bacteremia via agents from thrombophlebitis. The patient is in a good condition following surgery, antimicrobial treatment, and radiotherapy.
Insights
Intracranial abscesses, rare infections within brain tumors, present diagnostic challenges. Early surgical intervention combined with antimicrobial therapy is crucial for patient survival and improved outcomes.
Area of Science:
- Neurology
- Infectious Diseases
- Oncology
Background:
- Intracranial abscesses superimposed on brain tumors are rare but serious complications.
- Diagnosis can be challenging due to subtle or absent signs of infection.
Observation:
- A patient presented with an intracranial abscess associated with Glioblastoma Multiforme.
- Staphylococcus aureus was identified as the causative microbial agent.
- Bacteremia secondary to thrombophlebitis was the suspected route of infection.
Findings:
- Early surgical management of the abscess and tumor is vital.
- Post-operative antimicrobial treatment and radiotherapy were administered.
- The patient demonstrated a positive clinical response following the comprehensive treatment strategy.
Implications:
- This case highlights the importance of considering intracranial abscesses in brain tumor patients.
- Treatment requires a multidisciplinary approach, integrating neurosurgery, infectious disease, and oncology.
- Adjusting oncological treatment post-infection is essential to prevent recurrence and ensure long-term patient management.
