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Updated: Jul 6, 2026

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
Published on: July 16, 2016
Beta cell mass in diabetes: a realistic therapeutic target?
1Department of Medicine I, St Josef-Hospital, Ruhr-University of Bochum, Gudrunstr. 56, 44791, Bochum, Germany. juris.meier@rub.de
Abstract:
Beta cell deficiency underlies both type 1 and type 2 diabetes, and restoration or replacement of beta cell function is therefore the logical long-term solution to therapy. This review sets out to describe the defects in beta cell mass and function in both forms of diabetes, summarises current understanding of the underlying causes of beta cell death, and the methodological limitations of determining beta cell mass in vivo. Finally, the potential effects of current and future treatment regimens on beta cell mass and turnover are considered.
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