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Related Experiment Video

Updated: Jul 6, 2026

Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins

Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins

Published on: January 26, 2019

A shuttling molecular machine with reversible brake function.

Keiji Hirose¹, Yoshinobu Shiba, Kazuaki Ishibashi

¹Division of Frontier Materials Science, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka, Japan. hirose@chem.es.osaka-u.ac.jp

Chemistry (Weinheim an Der Bergstrasse, Germany)

|March 5, 2008

Summary

This summary is machine-generated.

Researchers developed a novel molecular machine that can shuttle and brake on command. This photochemical and thermal control over molecular motion offers new possibilities in nanotechnology.

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Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins

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Published on: November 3, 2010

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

Published on: March 13, 2019

Area of Science:

Supramolecular Chemistry
Nanotechnology
Materials Science

Background:

Molecular machines are crucial for nanoscale operations.
Controlling molecular motion is key for advanced applications.
Rotaxanes offer a promising platform for molecular machinery.

Purpose of the Study:

To design and demonstrate a shuttling molecular machine with a reversible brake.
To investigate photochemical and thermal control over molecular motion.
To develop a prototype for advanced nanoscale devices.

Main Methods:

Synthesis of a rotaxane molecular machine with specific ring and axle components.
Utilizing photochemical stimuli (photoirradiation) to alter macrocycle size.
Employing thermal stimuli (thermal ring opening) to revert macrocycle size.

Main Results:

Demonstrated a shuttling molecular machine prototype.
Achieved a reversible brake function by altering macrocycle size.
Reduced shuttling rate by over 99% (<2.5 s(-1)) via photoirradiation.
Restored original shuttling rate using thermal stimuli.

Conclusions:

Successfully designed and demonstrated a molecular machine with a reversible brake.
Photochemical and thermal stimuli provide precise control over molecular shuttling.
This work advances the development of switchable molecular devices.