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[Receptor specificity of human enteroviruses]

F A Fadeev, A G Sergeev, A V Novoselov

    Voprosy Virusologii
    |March 6, 2008
    PubMed

    Insights

    This review examines enterovirus receptor specificity, exploring how alterations in this specificity influence viral reproduction both in lab settings and within living organisms. Understanding these changes is key to controlling enterovirus infections.

    Area of Science:

    • Virology
    • Molecular Biology

    Context:

    • Enteroviruses are a significant group of viruses with diverse clinical manifestations.
    • Receptor interactions are crucial for viral entry and replication.

    Purpose:

    • To consolidate current knowledge on enterovirus receptor specificity.
    • To evaluate the potential impact of altered receptor specificity on viral reproduction.

    Summary:

    • This review synthesizes available data on enterovirus receptor usage.
    • It investigates the link between changes in receptor specificity and the efficiency of enterovirus replication in vitro and in vivo.
    • The role of specific cellular receptors in determining enterovirus tropism and pathogenesis is discussed.

    Impact:

    • Provides a foundation for understanding enterovirus evolution and adaptation.
    • Highlights potential targets for antiviral therapies.
    • Informs strategies for predicting and managing enterovirus outbreaks.

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