[Development, manufacture and sales of products for diagnosis of disease]

Final version of "Chronic kidney disease (CKD) Practice Guide" book is displayed on the Japanese Society of Nephrology (JSN) homepage in April, 2007. JSN epidemiology working-group finally approved the glomerular filtration rate (GFR) estimation equation for Japanese. Serum creatinine (Cr) should be measured by enzyme method. The modified the abbreviated MDRD Study equation for Japanese is already printed in the "CKD practice guide". GFR = 175 x Cr(-1.154) x Age (-0.203) x 0.741 (if women 0.742) The limit of detection of enzymatic method of serum creatinine is at least 0.02 mg/dL to evaluate GFR accurately. Moreover, Japanese Government will assume decreasing the number of the prevalence and reserve of the lifestyle related disease up to present 25% to be a policy objective by 2015. And, it obligated the checkup and the health guidance specially provided to the employee of 40 years or more who worked in each corporation to be executed on April 1, 2008. The spread of the automatic clinical analyzer reduces a necessary amount of the specimen and the amount of the reagent, and has reduced time and the cost of clinical chemistry test greatly. The environment of the clinical examination will change in the future, and useful information for the patient and the doctor change again like this. To offer information suitable for needs in the changing age, the researcher who works at the site of the clinical examination and the researcher who works at the site of the reagent development should cooperate mutually, and continue study and the effort.