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Updated: Jul 6, 2026
09:43
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
[Crescentic and necrotizing glomerulonephritis with C3 deposition].
Yukiko Tsukada1, Yoshinori Wakabayashi, Yasuko Suetsugu
1Department of Nephrology, Numazu City Hospital, Shizuoka, Japan.
Nihon Jinzo Gakkai Shi
|March 6, 2008
Summary
Severe post-infectious glomerulonephritis can lead to acute renal failure. This condition is characterized by crescentic and necrotizing glomerulonephritis with C3 deposition, often requiring hemodialysis.
Area of Science:
- Nephrology
- Immunology
- Pathology
Background:
- Post-infectious glomerulonephritis (PIGN) is an immune-mediated renal disease.
- It typically follows infections, particularly streptococcal, and can present with acute renal failure.
Observation:
- Two cases of severe PIGN are presented, both with acute renal failure and characteristic pathological findings.
- Case 1 involved a 38-year-old female with lung edema and rapidly progressive renal failure requiring maintenance hemodialysis.
- Case 2 involved a 28-year-old female with pharyngitis and acute renal failure, who improved with hemodialysis but has persistent chronic renal failure.
Findings:
- Renal biopsies in both cases revealed crescentic and necrotizing glomerulonephritis with C3 deposition.
- Immunofluorescence showed granular C3 deposition, with a "starry sky" pattern in one case.
- Electron microscopy identified glomerular subepithelial deposits.
Implications:
- These findings highlight the severe spectrum of PIGN and its potential for poor renal outcomes.
- Aggressive management including hemodialysis and immunosuppression may be necessary.
- Further research into PIGN pathogenesis and treatment is warranted.
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