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Application of immunohistochemistry to thyroid neoplasms
1Department of Pathology, University Health Network and Toronto Medical Laboratories, 200 Elizabeth St, 11th Floor, Toronto, Ontario, Canada M5G 2C4.
Archives of Pathology & Laboratory Medicine
|March 6, 2008
Summary
Immunohistochemistry aids in diagnosing difficult thyroid lesions. Utilizing antibody panels and molecular analysis alongside standard methods improves diagnostic accuracy for thyroid nodules.
Area of Science:
- Endocrinology
- Pathology
- Oncology
Background:
- Thyroid lesions with nodular and follicular growth patterns present diagnostic challenges in cytologic and histologic assessments.
- Misdiagnosis of follicular neoplasms or tumors of uncertain malignant potential can delay patient management.
- Accurate diagnosis of unusual or metastatic thyroid tumors often necessitates immunohistochemical confirmation.
Purpose of the Study:
- To conduct a literature review on the utility of immunohistochemistry in the differential diagnosis of thyroid tumors.
Main Methods:
- A comprehensive literature search was performed using PubMed.
- Articles indexed between 1976 and 2006 were included in the review.
Main Results:
- The review identified various applications of immunohistochemistry in thyroid tumor diagnosis.
- Ancillary techniques, including immunohistochemistry and molecular analysis, were highlighted.
Conclusions:
- The use of immunohistochemistry panels and molecular analysis is supported for assessing thyroid nodules.
- These techniques, when integrated with conventional morphologic criteria, enhance diagnostic accuracy for thyroid tumors.
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