Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

Intrauterine Drug Delivery Systems

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Bioavailability Enhancement: Drug Permeability Enhancement

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...

Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

Oral Drug Delivery Systems: Continuous-Release Systems

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Editorial.

International journal of pharmaceutics: X·2026

Same author

Perilymph sampling in Mongolian gerbil, technical note and procedure evaluation.

Hearing research·2025

Same author

Release of liposomes from hyaluronic acid-based hybrid systems: effects of liposome surface and size.

International journal of pharmaceutics·2024

Same author

Machine learning of Raman spectra predicts drug release from polysaccharide coatings for targeted colonic delivery.

Journal of controlled release : official journal of the Controlled Release Society·2024

Same author

Development of a Semi-Automated Approach for the Quantification of Neuronal Cells in the Spiral Ganglion of the Whole Implanted Gerbil Cochlea, Acquired by Light-Sheet Microscopy.

Audiology & neuro-otology·2024

Same author

Poly(D,l-lactide-co-glycolide) particles are metabolised by the gut microbiome and elevate short chain fatty acids.

Journal of controlled release : official journal of the Controlled Release Society·2024

Search research articles

Related Experiment Video

Updated: Jul 6, 2026

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

Lipid implants as drug delivery systems.

Frauke Kreye¹, Florence Siepmann, Juergen Siepmann

¹University of Lille, College of Pharmacy, JE 2491, 3, rue du Professeur Laguesse, 59006 Lille, France.

Expert Opinion on Drug Delivery

|March 6, 2008

Summary

Lipid implants offer a superior alternative to traditional polymers for parenteral controlled drug delivery, especially for sensitive protein drugs. They avoid acidic microclimates and provide versatile release patterns, overcoming limitations of poly(lactic-co-glycolic acid) systems.

More Related Videos

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications

Published on: November 17, 2015

Related Experiment Videos

Last Updated: Jul 6, 2026

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications

Published on: November 17, 2015

Area of Science:

Biomaterials Science
Drug Delivery Systems
Polymer Chemistry

Background:

Parenteral controlled delivery of acid-labile drugs faces challenges with conventional poly(lactic-co-glycolic acid) (PLGA) implants.
PLGA degradation generates acidic byproducts, creating unfavorable microenvironments for sensitive drugs like proteins.
Lipid implants present a promising alternative, circumventing the acidic microclimate issue.

Purpose of the Study:

To provide a comprehensive overview of lipid-based parenteral controlled drug delivery systems.
To highlight the advantages and disadvantages of various lipid implant formulations.
To discuss preparation techniques, drug release mechanisms, and in vivo performance.

Main Methods:

Literature review of existing lipid implant systems for parenteral drug delivery.
Analysis of preparation methods, including extrusion, molding, and melt-dispersion.
Evaluation of mass transport mechanisms (diffusion, erosion, swelling) and drug release kinetics.
Assessment of biocompatibility and in vivo performance data from preclinical studies.

Main Results:

Lipid implants demonstrate effective controlled release of various drugs, particularly proteins.
They avoid the formation of acidic microclimates, preserving drug integrity.
A wide range of release profiles can be achieved by tailoring lipid composition and formulation.
Biocompatibility and in vivo performance are generally favorable.

Conclusions:

Lipid implants are a highly promising platform for parenteral controlled drug delivery, especially for acid-labile biologics.
Their ability to avoid acidic degradation byproducts and offer tunable release makes them advantageous over PLGA systems.
Further research into optimized lipid formulations and manufacturing processes will enhance their clinical utility.