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Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Tuberculosis01:23

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Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
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Related Experiment Video

Updated: Jul 6, 2026

Merkel Cell Polyomavirus Infection and Detection
13:45

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

Morgellons disease?

Robert E Accordino1, Danielle Engler, Iona H Ginsburg

  • 1Department of Medical Education, Mount Sinai School of Medicine, New York, NY 10029, USA. Robert.accordino@mssm.edu

Dermatologic Therapy
|March 6, 2008
PubMed
Summary

Morgellons disease, a condition with skin symptoms, shares similarities with delusions of parasitosis. A therapeutic alliance, including topical treatments and antipsychotics, can improve patient outcomes.

Area of Science:

  • Dermatology
  • Psychiatry

Background:

  • Morgellons disease is a poorly understood condition characterized by skin symptoms.
  • It shares significant overlap with delusions of parasitosis, a psychiatric condition.

Observation:

  • Morgellons disease has a long history but has gained recent attention.
  • Patients often present with unexplained skin sensations and perceived infestations.

Findings:

  • The diagnostic term 'Morgellons disease' can be used to build trust with patients.
  • A therapeutic alliance involving empathy and validation is crucial.

Implications:

  • Combining topical treatments with antipsychotic medications may be beneficial.
  • A patient-centered approach can improve treatment adherence and outcomes for Morgellons disease.

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