Related Experiment Video
Updated: Jul 6, 2026

05:39
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
Granulomatous rosacea-like demodicidosis.
Julia Yu-Yun Lee1, Chao-Kai Hsu
1Department of Dermatology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. yylee@mail.ncku.edu.tw
Dermatology Online Journal
|March 6, 2008
Summary
Demodex granuloma can mimic granulomatous rosacea. Identifying extrafollicular Demodex mites in skin biopsies is crucial for accurate diagnosis and effective treatment of demodicidosis.
Area of Science:
- Dermatology
- Parasitology
Background:
- Demodicidosis encompasses various presentations, including pityriasis folliculitis and rosacea-like eruptions.
- Demodex mites are implicated in several dermatological conditions.
Observation:
- A middle-aged woman presented with recurrent facial papules resembling granulomatous rosacea.
- Skin biopsy revealed extrafollicular Demodex mites within a perifollicular inflammatory infiltrate.
Findings:
- The patient was diagnosed with demodicidosis (Demodex granuloma).
- Treatment with systemic and topical metronidazole, plus low-dose oral prednisolone, led to papule resolution within 3 weeks.
Implications:
- Demodex granuloma can be misdiagnosed as granulomatous rosacea.
- Histopathological identification of extrafollicular Demodex mites is key for correct diagnosis.
- This case highlights the importance of considering demodicidosis in rosacea-like presentations.
Related Concept Videos
Rocky Mountain Spotted Fever
Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Rheumatic Heart Disease I: Introduction
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

