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Related Experiment Video

Updated: Jul 6, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Linear porokeratosis.

S K Malhotra¹, K J P S Puri, Tanu Goyal

¹Government Medical College, Amritsar, India.

Dermatology Online Journal

|March 6, 2008

Summary

This summary is machine-generated.

Linear porokeratosis is a rare skin condition presenting in childhood or adulthood. This case highlights an atypical proximal presentation, emphasizing its rarity and potential for malignant transformation.

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Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis

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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis

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Published on: May 16, 2020

Area of Science:

Dermatology
Genetics
Histopathology

Background:

Linear porokeratosis is a rare genodermatosis characterized by lesions following Blaschko's lines.
Typically, lesions affect distal extremities, but atypical presentations occur.
The etiology is linked to abnormal epidermal precursor clones.

Observation:

A 20-year-old male presented with lifelong annular plaques in a linear pattern on his left upper limb and trunk.
Lesions exhibited atrophic centers with raised, hyperkeratotic borders, predominantly on proximal areas.
Histopathology revealed hyperkeratosis, parakeratosis, a coronoid lamella, and dermal pigment incontinence.

Findings:

The case presents an atypical proximal distribution of linear porokeratosis, differing from the usual distal predilection.
Histopathological findings confirmed classic features of porokeratosis, including the coronoid lamella.
No family history or systemic abnormalities were noted in the patient.

Implications:

This case underscores the variability in clinical presentation of linear porokeratosis.
Early diagnosis and monitoring are crucial due to the associated risk of malignant transformation.
Further research into the genetic and cellular mechanisms of porokeratosis is warranted.