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Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA

Michael S Y Huen1, Shirley M-H Sy, Jan M van Deursen

  • 1Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

The Journal of Biological Chemistry
|March 6, 2008
PubMed
Summary

The histone methyltransferase SET8 (also known as Pr-Set7) monomethylates histone H4 during S phase, a process crucial for cell division. SET8 is essential for embryonic development, as its deletion in mice leads to embryonic lethality.

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