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Related Concept Videos

Good Manufacturing Practices01:26

Good Manufacturing Practices

Good Manufacturing Practices (GMP) constitute a foundational set of guidelines that ensure the production of safe, consistent, and high-quality products, particularly in industries such as pharmaceuticals, biotechnology, and food processing. These protocols encompass all aspects of production, from the sourcing of raw materials to the final distribution of the finished product.A core pillar of GMP is stringent hygiene and sanitation across all production environments. This includes routine...
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Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
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Pharmacological activation of NO-cGMP signalling attenuates metabolic dysfunction-associated steatohepatitis.

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Updated: Jul 6, 2026

Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies
09:30

Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

Published on: March 17, 2023

Meeting report: cGMP matters.

Barbara Kemp-Harper1, Robert Feil

  • 1Department of Pharmacology and Centre for Vascular Health, Monash University, Clayton, Victoria, Australia. Barbara.Kemp@med.monash.edu.au

Science Signaling
|March 6, 2008
PubMed
Summary
This summary is machine-generated.

Cyclic guanosine 3

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Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Biochemistry

Background:

  • The second messenger cyclic guanosine 3',5'-monophosphate (cGMP) is crucial for cellular functions like growth and contractility.
  • cGMP is generated by guanylyl cyclases in response to natriuretic peptides or nitric oxide.
  • cGMP signaling pathways involve effectors such as phosphodiesterases and protein kinases.

Framework:

  • This report focuses on new data concerning the cGMP signaling system.
  • Key areas include molecular mechanisms, pathophysiological relevance, and therapeutic potential.
  • The information was presented at the 3rd cGMP meeting in Dresden, Germany.

Implementation:

  • The study summarizes recent advancements in understanding cGMP.
  • It highlights the role of cGMP in various cellular processes.
  • The data presented offers insights into the cGMP signaling network.

Implications:

  • Modulating cGMP levels shows promise for treating cardiovascular disorders.
  • Understanding cGMP mechanisms can lead to novel therapeutic strategies.
  • The cGMP signaling system represents a significant target for drug development.