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Endoscopic ultrasonography in hepatology: focus on portal hypertension
C De Angelis1, R Pellicano, P Carucci
1Department of Gastro-Epatology, San Giovanni Battista (Molinette), Hospital, Corso Bramante 88, Turin, Italy. eusdeang@hotmail.com
Insights
Endoscopic ultrasound (EUS) aids in diagnosing portal hypertension (PHT) and gastroesophageal varices (GEV). While EUS provides detailed insights, its direct clinical impact on patient outcomes requires further scientific evidence.
Area of Science:
- Gastroenterology
- Medical Imaging
- Hepatology
Background:
- Portal hypertension (PHT), often caused by cirrhosis, leads to gastroesophageal varices (GEV) and bleeding risks.
- Accurate diagnosis of PHT and GEV is critical for prevention and management.
- Existing diagnostic methods have limitations in comprehensively assessing the portal venous system and collateral circulation.
Purpose of the Study:
- To evaluate the role of Endoscopic Ultrasound (EUS) in diagnosing portal hypertension and gastroesophageal varices.
- To assess the utility of EUS in evaluating the portal venous system and porto-systemic collateral circulation.
- To explore EUS's potential in risk stratification, treatment monitoring, and guiding therapy for PHT and GEV.
Main Methods:
- Utilized Endoscopic Ultrasound (EUS) with advanced imaging and Color-Doppler capabilities.
- Integrated EUS findings with standard video-endoscopy for comprehensive GEV assessment.
- Analyzed EUS data for hemodynamic information and risk stratification of PHT patients.
Main Results:
- EUS offers a comprehensive evaluation of the portal venous system and collateral circulation.
- Improved endoscopic views from video-echoendoscopes enhance GEV diagnosis and bleeding risk assessment.
- EUS with Color-Doppler provides crucial hemodynamic data for PHT and GEV management.
Conclusions:
- EUS provides extensive data for stratifying PHT severity and bleeding risk.
- EUS can monitor treatment response, predict recurrence, and guide endoscopic therapy.
- Further scientific evidence is needed to confirm the clear clinical impact of EUS on patient outcomes.
Abstract:
Portal hypertension (PHT) is more frequently caused by cirrhosis. Increase in portal pressure induces development of collateral circulation with shunting resulting in disturbances such as gastroesophageal varices (GEV). Prevention and therapy of bleeding from GEV are mandatory. Therefore, the diagnosis of PHT represents a crucial step. Endoscopic ultrasound (EUS), with its combination of endoscopic imaging and ultrasonic capabilities, can offer an almost comprehensive evaluation of portal venous system and porto-systemic collateral circulation. The improved endoscopic view of several video-echoendoscopes has filled the gap between EUS and standard video-endoscopy in diagnosing GEV and in assessing endoscopic criteria of bleeding risk. EUS combined with Color-Doppler capabilities are able to provide hemodynamic information. Furthermore, EUS data allow to stratify patients on the basis of PHT severity and first bleeding risk, monitor the results of pharmacologic and/or endoscopic therapy, predict the response to treatment, quantify the risk of variceal recurrence and recurrent bleeding after GEV obliteration and guide or assist EGD therapy. Despite having this amount of information, there is lack of scientific evidence that EUS imaging and EUS-assisted therapy can have a clear-cut clinical impact and affect patients outcome.
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