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Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
Published on: August 20, 2018
Toward the Total Synthesis of Scleritodermin A: Preparation of the C(1)-N(15) Fragment
Diver Sellanes1, Eduardo Manta, Gloria Serra
1Cátedra de Química Farmacéutica, Departamento de Química Orgánica, Facultad de Química, UDELAR, Av. General Flores 2124, C. C. 1157, Montevideo, Uruguay.
Tetrahedron Letters
|March 6, 2008
Abstract:
The synthesis of the C(1)-N(15) fragment of the marine natural product Scleritodermin A has been accomplished through a short and stereocontrolled sequence. Highlights of this route include the synthesis of the novel ACT fragment and the formation of the alpha-keto amide linkage by the use of a highly activated alpha, beta-ketonitrile.
