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Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Tumor Progression

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Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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Related Experiment Video

Updated: Jul 6, 2026

RhoC GTPase Activation Assay

RhoC GTPase Activation Assay

Published on: August 22, 2010

CXCL5 promotes prostate cancer progression.

Lesa A Begley¹, Sathish Kasina, Rohit Mehra

¹Department of Urology, University of Michigan, Ann Arbor, MI 48109-0944, USA.

Neoplasia (New York, N.Y.)

|March 6, 2008

Summary

Chemokine CXCL5 (C-X-C motif chemokine ligand 5) promotes prostate tumor growth and invasion. Its elevated levels in prostate tissues correlate with malignancy, suggesting a role in both benign and cancerous prostate diseases.

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Area of Science:

Oncology
Immunology
Cell Biology

Background:

CXCL5 is a proangiogenic chemokine involved in inflammation and immune cell attraction.
It is secreted by various immune and non-immune cells.
Its role in prostate tissue, particularly in relation to malignancy, is not fully understood.

Purpose of the Study:

To investigate CXCL5 expression in normal and malignant human prostate tissues.
To determine the correlation between CXCL5 levels and prostate cancer progression.
To assess the biological effects of CXCL5 on prostate epithelial cells.

Main Methods:

Immunohistochemistry to detect CXCL5 protein expression in prostate tissues.
Analysis of CXCL5 expression in relation to tumor grade and stage.
In vitro experiments applying exogenous CXCL5 to prostate epithelial cells to assess proliferation, gene transcription, and invasion.

Main Results:

CXCL5 protein levels increase with prostate tumor progression.
CXCL5 expression is strongly associated with inflammatory cell infiltration.
CXCL5 stimulates proliferation and gene transcription in prostate epithelial cells and enhances invasion of aggressive cancer cells.

Conclusions:

CXCL5 protein expression correlates with prostate tumor progression and inflammatory infiltrate.
CXCL5 can stimulate cellular proliferation and invasion, suggesting a role in prostate cancer.
CXCL5 may contribute to the development of both benign and malignant prostate proliferative diseases.