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Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping
S Tominaga1, N A Jenkins, D J Gilbert
1Department of Biochemistry II, Jichi Medical School, Tochigi, Japan.
Abstract:
The genomic locus of the murine ST2 gene was isolated based on homology with a murine ST2 complementary DNA sequence and its complete nucleotide sequence was determined. The locus is composed of eight exons and seven introns and is approx. 9 kilobase pairs in size. Two Sp1 binding sites are present in the 5' flanking region. The murine ST2 gene, which was expressed only in the growth-stimulated BALB/c-3T3 cells, was mapped to mouse chromosome one, very tightly linked to the interleukin 1 receptor-type 1 locus.
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