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Related Experiment Videos

Decrease in erythrocyte survival in Theileria sergenti-infected calves determined by non-radioactive chromium

Y Yagi1, N Ito, I Kunugiyama

  • 1Systematic Diagnosis Research Division, National Institute of Animal Health, Ibaraki, Japan.

The Journal of Veterinary Medical Science
|June 1, 1991
PubMed
Summary

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Anemia in calves infected with Theileria sergenti is caused by decreased red blood cell survival. Even non-parasitized red blood cells showed reduced survival, indicating a broader impact beyond direct infection.

Area of Science:

  • Veterinary Medicine
  • Parasitology
  • Hematology

Background:

  • Theileria sergenti infection is a significant cause of anemia in cattle.
  • The precise mechanisms of anemia pathogenesis in these infections require further elucidation.

Purpose of the Study:

  • To investigate the pathogenesis of anemia in calves infected with Theileria sergenti.
  • To evaluate the role of erythrocyte survival decrease in the development of anemia.

Main Methods:

  • Erythrocyte survival was assessed using non-radioactive chromium (50Cr) labeling.
  • Labeled erythrocytes were reintroduced into the original donor calves for survival rate determination.

Main Results:

  • A marked decrease in erythrocyte survival was observed in Theileria sergenti-infected calves compared to uninfected controls.

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  • On day four, survival rates were 25.7% for infected calves versus 86.0% for uninfected calves.
  • Non-parasitized erythrocytes in infected calves also exhibited decreased survival, suggesting no direct correlation with parasite load.

    • Conclusions:

    • Reduced erythrocyte survival is a key factor in the pathogenesis of anemia associated with Theileria sergenti infection.
    • The decrease in erythrocyte survival affects both parasitized and non-parasitized red blood cells, indicating a systemic effect.