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Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Articles linked to this work by shared authors, journal, and citation graph.

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Study of the rare decays of [Formula: see text] and [Formula: see text] into muon pairs from data collected during the LHC Run 1 with the ATLAS detector.

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Measurements of top-quark pair differential cross-sections in the lepton+jets channel in <i>pp</i> collisions at [Formula: see text] using the ATLAS detector.

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Search for squarks and gluinos in events with hadronically decaying tau leptons, jets and missing transverse momentum in proton-proton collisions at [Formula: see text] TeV recorded with the ATLAS detector.

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Updated: Jul 6, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

[Antibiotic therapy in pregnancy]

A Haas1, G Maschmeyer

  • 1Medizinische Klinik, Abt. Hämatologie und Onkologie, Klinikum Ernst von Bergmann, Potsdam. ahaas@klinikumevb.de

Deutsche Medizinische Wochenschrift (1946)
|March 6, 2008
PubMed
Summary

Pregnant women face infection risks, potentially causing abortion or preterm birth. Beta-lactam antibiotics like penicillins and cephalosporins are generally safe, with specific macrolides and other agents used cautiously.

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Pharmacology

Context:

  • Infections pose significant risks during pregnancy, leading to adverse outcomes like abortion and preterm birth.
  • Maternal and fetal health are threatened by both pregnancy-related and non-pregnancy-associated infections.
  • Clinical uncertainty often surrounds the appropriate management of infections in pregnant individuals.

Purpose:

  • To provide guidance on the safe and effective antimicrobial treatment of infections during pregnancy.
  • To outline antibiotic choices, highlighting safety profiles and potential risks for both mother and fetus.
  • To inform clinical decision-making regarding antibiotic selection in obstetric patients.

Summary:

  • Beta-lactam antibiotics, including penicillins and first-generation cephalosporins, are generally considered safe and effective.

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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  • Erythromycin is the preferred macrolide; clindamycin and metronidazole are potential second-line options.
  • Certain antibiotics like tetracyclines, sulfonamides, chloramphenicol, and quinolones have specific restrictions or contraindications during pregnancy.

    • Impact:

    • Facilitates evidence-based prescribing of antibiotics during pregnancy, improving maternal and fetal outcomes.
    • Reduces the risk of adverse drug reactions and teratogenicity by guiding appropriate antibiotic selection.
    • Empowers healthcare providers with clear recommendations for managing infections in pregnant patients, enhancing patient safety.