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Updated: Jul 6, 2026

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
[Cryptogenic and secondary organizing pneumonia]
1Service de pneumologie, BHHC, hôpital universitaire de Berne, 3010 Berne, Suisse. romain.lazor@insel.ch
Abstract:
Organising pneumonia is an inflammatory and fibroproliferative reaction of the lung, which gives rise to a clinico-pathological syndrome. It may occur without any detectable cause (cryptogenic organising pneumonia) or may be associated with various processes such as infections, drug toxicities, connective tissue disorders, etc. (secondary organising pneumonia). The clinical picture is usually subacute and includes fever, fatigue, weight loss, cough, dyspnea, crackles, and elevated inflammatory markers. At imaging, the most typical pattern consists of multiple subpleural consolidations. Bronchoalveolar lavage reveals a mixed alveolitis with lymphocytes and polymorphonuclear cells. Lung biopsy shows buds of loose connective tissue filling the lung alveoli. The diagnosis is made by combination of clinical, imaging and histopathological criteria. Most patients respond very well to corticosteroid therapy. Relapses are common but can usually be controlled with moderate doses of prednisone, and do not worsen the prognosis.
Insights
Organising pneumonia is an inflammatory lung condition with subacute symptoms like fever and cough. Most patients respond well to corticosteroid therapy, with relapses usually manageable.
Area of Science:
- Pulmonology
- Pathology
Context:
- Organising pneumonia presents as an inflammatory and fibroproliferative lung reaction.
- It can be idiopathic (cryptogenic organising pneumonia) or secondary to infections, drug toxicities, or connective tissue disorders.
Purpose:
- To define the clinico-pathological syndrome of organising pneumonia.
- To outline its causes, clinical presentation, diagnostic criteria, and treatment response.
Summary:
- Characterized by subacute symptoms including fever, fatigue, weight loss, cough, dyspnea, crackles, and elevated inflammatory markers.
- Imaging typically shows subpleural consolidations; bronchoalveolar lavage reveals mixed alveolitis; lung biopsy demonstrates connective tissue buds in alveoli.
- Diagnosis relies on integrating clinical, imaging, and histopathological findings.
Impact:
- Organising pneumonia is a treatable condition with corticosteroids, leading to good patient outcomes.
- While relapses are common, they are generally controlled with prednisone and do not adversely affect the long-term prognosis.
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