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Updated: Jul 6, 2026

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
Published on: July 16, 2014
Brivaracetam: a new drug in development for epilepsy and neuropathic pain
Barbara Malawska1, Katarzyna Kulig
1Jagiellonian University Medical College, Department of Physicochemical Drug Analysis, 30-688 Kraków, Medyczna 9, Poland. mfmalaws@cyf-kr.edu.pl
Background:
Epilepsy is a neurological disorder with a worldwide prevalence estimated to be 0.5-1.0% of the population. Many potent antiepileptic drugs (AED) have been used for treatment but still about 30% of patients are resistant to current AEDs. Some AEDs are also used for the treatment of neuropathic pain.
Objective:
The aim of this report is to present preclinical and clinical studies of brivaracetam (UCB-34714), a new drug developed by UCB Pharma.
Methods:
Published results of preclinical studies in several animal models of epilepsy, neuropathic pain, essential tremor and results of Phase I and II evaluations of brivaracetam have been analysed.
Results/Conclusion:
Brivaracetam represents a new mechanism of action being a ligand of synaptic vesicle protein 2A. It is undergoing Phase III evaluation after a successful Phase II programme in which was effective as an adjunctive treatment in partial-onset epilepsy (50 mg/day). It is well tolerated, without serious adverse side effects.
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