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Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway

Kiwamu Nakamura1, Akiko Miyazato, Gang Xiao

  • 1Department of Infection Control and Laboratory Diagnostics, Internal Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

Journal of Immunology (Baltimore, Md. : 1950)
|March 7, 2008
PubMed
Summary

Cryptococcal DNA activates immune cells called myeloid dendritic cells (BM-DCs) through Toll-like receptor 9 (TLR9). This interaction suggests a role for CpG DNA in the inflammatory response to fungal infections.

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