Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Relative Risk01:12

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Renal Drug Clearance: Overview01:06

Renal Drug Clearance: Overview

Renal clearance is a crucial parameter in pharmacokinetics that quantifies the rate at which the kidneys excrete a drug. It represents a constant fraction of the central volume of distribution containing the drug that the kidney eliminates per unit of time.
Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of a novel, digital physical activity and emotional well-being intervention on health-related quality of life in people with chronic kidney disease: trial design and baseline data from a multicentre prospective, wait-list randomised controlled trial (kidney BEAM).

BMC nephrology·2023
Same author

Symptom-burden in people living with frailty and chronic kidney disease.

BMC nephrology·2020
Same author

Biological variation of cardiac troponins in chronic kidney disease.

Annals of clinical biochemistry·2020
Same author

The epidemiology of hospitalised acute kidney injury not requiring dialysis in England from 1998 to 2013: retrospective analysis of hospital episode statistics.

International journal of clinical practice·2016
Same author

Is a reduction in albuminuria associated with renal and cardiovascular protection? A post hoc analysis of the ALTITUDE trial.

Diabetes, obesity & metabolism·2015
Same author

High sodium intake is associated with important risk factors in a large cohort of chronic kidney disease patients.

European journal of clinical nutrition·2014

Related Experiment Videos

Renal risk scores: progress and prospects.

M W Taal1, B M Brenner

  • 1Department of Renal Medicine, Derby Hospitals NHS Foundation Trust and Centre for Integrated Systems in Biology and Medicine, University of Nottingham, Derby City General Hospital, Derby, UK. Maarten.Taal@derbyhospitals.nhs.uk

Kidney International
|March 7, 2008
PubMed
Summary

Proteinuria is the key indicator for chronic kidney disease (CKD) progression. Identifying high-risk patients with CKD is crucial for better renal prognosis and cardiovascular risk assessment.

Related Experiment Videos

Area of Science:

  • Nephrology
  • Renal Medicine
  • Public Health

Background:

  • Widespread adoption of CKD classification and eGFR has identified many undiagnosed patients.
  • CKD is a heterogeneous condition, with only a minority progressing to end-stage renal disease.
  • There is a need for a simple risk assessment method for CKD patients.

Purpose of the Study:

  • To highlight proteinuria as a critical marker for renal risk.
  • To review existing risk factors and risk score development for CKD progression.
  • To emphasize the need for a generalizable renal risk score.

Main Methods:

  • Review of existing literature on proteinuria and CKD prognosis.
  • Analysis of studies correlating proteinuria levels and changes with renal outcomes.
  • Discussion of attempts to develop risk scores for CKD progression.

Main Results:

  • Proteinuria magnitude is a significant predictor of renal prognosis.
  • Changes in proteinuria after antihypertensive treatment correlate with prognosis.
  • Proteinuria is the most important marker of renal risk.

Conclusions:

  • Proteinuria is the single most important marker for assessing renal risk in chronic kidney disease.
  • Further research is needed to develop and validate a universal renal risk score for CKD patients.
  • Similar methodologies can be applied to assess cardiovascular risk in CKD.