Related Experiment Video
Updated: Jul 6, 2026

Ex vivo Culture of Human Placental Explants for the Study of Viral Transmission Across the Maternal-Fetal Interface
Published on: December 30, 2025
[Clinical prospective study on maternal-fetal transmission of human bocavirus]
Min-qiao Zheng1, Feng Lin, Mei-yun Zheng
1Wenling Hospital, Wenzhou Medical College, Wenzhou 317500, China.
Objective:
To investigate maternal-fetal transmission at human bocavirus (HBoV).
Methods:
IgG antibody to HBoV in serum samples of 316 mothers were determined with ELISA and HBoV DNA was determined with real time PCR in the sera of the mothers and their infants.
Results:
HBoV-IgG was positive in 40.20 percent (127/316) of the mothers, while it was positive in 29.43 percent (93/316) of the cord blood specimens of the infants. The difference between the two groups was significant (X2=8.12, P less than 0.005); 93 samples of both the mothers and the infants were positive for HBoV-IgG.
Conclusion:
HBoV-IgG can cross the placenta to the fetuses through placenta. Further study is needed to answer the question whether vertical maternal-fetal transmission occurs.
Related Concept Videos
Development of the Oral Microbiota
Teratogenicity
Development of Human Microbiota
Toxoplasmosis
Respiratory Syncytial Virus Disease

