Related Experiment Videos
Premedication and short term complications in iohexol discography
K Tallroth1, J Soini, I Antti-Poika
1Department of Radiology, Orthopaedic Hospital of the Invalid Foundation, Helsinki, Finland.
Annales Chirurgiae Et Gynaecologiae
|January 1, 1991
Summary
Iohexol discography for lumbar discs showed immediate adverse reactions like nausea and convulsions, likely due to the procedure, not the contrast medium. Post-procedure, headache and low back pain were common, with 81% experiencing increased pain.
Area of Science:
- Radiology
- Pain Management
- Neurosurgery
Background:
- Lumbar discography is a diagnostic tool for low back pain.
- Non-ionic contrast media are used in discography.
- Understanding the safety profile of contrast agents is crucial.
Purpose of the Study:
- To evaluate the safety and tolerability of iohexol in lumbar discography.
- To assess immediate and delayed adverse events associated with iohexol discography.
- To investigate the relationship between injection pain and analgesic requirements.
Main Methods:
- 52 patients underwent lumbar discography with iohexol (180 mg/ml).
- Lateral injection technique with fluoroscopy control was used.
- Patients received either diazepam alone or diazepam with pethidine and glycopyrronium bromide premedication.
Main Results:
- No significant difference in injection pain between premedication groups.
- Immediate adverse events included nausea (2%), convulsions (4%), back pain (6%), and hypotension (10%).
- Delayed complications included severe headache (10%) and increased low back pain (81%).
Conclusions:
- Immediate reactions are likely procedure-related, not specific to iohexol.
- Delayed headache may be linked to cerebrospinal fluid leakage.
- Increased low back pain post-procedure could be due to local hematoma or chemical irritation.