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Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This makes...
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...

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Related Experiment Video

Updated: Jul 6, 2026

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation
04:42

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Published on: June 26, 2018

Sacral nerve stimulation in patients with severe constipation.

B Holzer1, H R Rosen, G Novi

  • 1Surgical Department, Danube Hospital-SMZ-Ost, Vienna, Austria.

Diseases of the Colon and Rectum
|March 7, 2008
PubMed
Summary

Sacral nerve stimulation improved severe chronic constipation in 42% of patients, significantly reducing symptoms and enhancing quality of life. Further research into pelvic floor function is recommended.

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Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
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Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

Published on: September 27, 2018

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Last Updated: Jul 6, 2026

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation
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Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Published on: June 26, 2018

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
08:17

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

Published on: September 27, 2018

Area of Science:

  • Gastroenterology
  • Neurology

Background:

  • Constipation is a complex condition with multiple contributing factors.
  • Severe chronic constipation poses significant challenges in patient management.

Purpose of the Study:

  • To evaluate the efficacy of sacral nerve stimulation (SNS) for treating severe chronic constipation.
  • To assess the impact of SNS on colonic transit time and rectal outlet obstruction.

Main Methods:

  • Nineteen patients with severe constipation underwent temporary sacral nerve stimulation lead implantation.
  • Permanent systems were implanted in patients showing improvement during the evaluation period.
  • Outcomes were assessed based on bowel movement frequency, need for digital manipulation, and Wexner constipation scores.

Main Results:

  • Forty-two percent of patients experienced significant constipation improvement after sacral nerve stimulation.
  • A notable decrease in Wexner constipation scores was observed 12 months post-implantation.
  • Patients reported a significant enhancement in their overall quality of life.

Conclusions:

  • Sacral nerve stimulation is a viable option for select patients with severe chronic constipation.
  • Further investigation into pelvic floor function is warranted to optimize SNS outcomes.