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Macrodystrophia lipomatosa with multiple entrapment neuropathies: a case report
Erkan Kozanoglu1, Filiz Koc, Kamil Goncu
1Department of Physical Medicine, Cukurova University Medical School, Adana, Turkey. ekozanoglu@yahoo.com
The International Journal of Neuroscience
|March 7, 2008
Summary
Macrodystrophia lipomatosa, a rare condition causing fibro-adipose tissue overgrowth, presented in a patient with limb enlargement and multiple nerve entrapments. This case highlights the association between this congenital malformation and entrapment neuropathies.
Area of Science:
- Medical Science
- Genetics
- Pathology
Background:
- Macrodystrophia lipomatosa is a rare, nonhereditary congenital malformation characterized by hypertrophic fibro-adipose tissues.
- It primarily affects mesenchymal structures, often involving the digits of the extremities.
- Previously referred to as macrodactyly, megalodactyly, or localized gigantism.
Observation:
- A 48-year-old male presented with unilateral enlargement of the right lower limb, particularly the first toe.
- The patient also exhibited tarsal tunnel syndrome.
- Despite no significant upper extremity involvement, bilateral cubital and unilateral carpal tunnel syndromes were identified.
Findings:
- The patient was diagnosed with macrodystrophia lipomatosa.
- Multiple entrapment neuropathies were detected concurrently with the limb overgrowth.
- This case underscores a potential association between macrodystrophia lipomatosa and nerve compression syndromes.
Implications:
- This case expands the understanding of macrodystrophia lipomatosa manifestations.
- It suggests a need for comprehensive neurological assessment in patients with this condition.
- Further research may elucidate the underlying mechanisms linking fibro-adipose overgrowth and nerve entrapment.
