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Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
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Metastasis02:30

Metastasis

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The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jul 6, 2026

Merkel Cell Polyomavirus Infection and Detection
13:45

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

[The Merkel cell carcinoma].

S Koscielny1

  • 1Klinik für Hals-Nasen-Ohrenheilkunde, Universitätsklinikum der Friedrich-Schiller-Universität Jena, Jena. sven.koscielny@med.uni-jena.de

Laryngo- Rhino- Otologie
|March 7, 2008
PubMed
Summary
This summary is machine-generated.

Merkel cell carcinoma is a rare subdermal tumor. Treatment involves surgery, radiation, and chemotherapy for metastatic disease.

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Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Context:

  • Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer originating from Merkel cells or pluripotent stem cells.
  • Etiology is largely unknown, but UV radiation and immunosuppression are significant risk factors.
  • Clinical presentation includes rapidly growing subcutaneous tumors, potentially with lymph node involvement.

Purpose:

  • To summarize the key aspects of Merkel cell carcinoma, including its origin, risk factors, clinical presentation, diagnosis, and treatment.
  • To highlight the importance of diagnostic tools like somatostatin-receptor-scintigraphy.
  • To outline the current therapeutic strategies for MCC.

Summary:

  • MCC arises from Merkel cells or subcutaneous stem cells, with UV exposure and immunosuppression as predisposing factors.
  • Diagnosis involves biopsy, imaging, and somatostatin-receptor-scintigraphy.
  • Standard treatment combines surgical resection, neck dissection, and radiation, with chemotherapy for metastatic cases.

Impact:

  • Provides a concise overview of Merkel cell carcinoma for researchers and clinicians.
  • Emphasizes current diagnostic and therapeutic standards for this rare malignancy.
  • Aids in understanding the multifaceted approach required for managing Merkel cell carcinoma.