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Opportunistic infections in immunologically compromised nonhuman primates.
Lynn M Wachtman1, Keith G Mansfield
1Harvard Medical School, Southborough, MA 01772-9012, USA.
ILAR Journal
|March 8, 2008
Summary
Opportunistic infections in research primates pose risks to animal health and research integrity. Understanding disease, surveillance, and risk reduction strategies are crucial for managing these health threats.
Area of Science:
- Veterinary Pathology
- Primate Medicine
- Infectious Diseases
Background:
- Nonhuman primates in research are susceptible to diseases causing immunodeficiency.
- Opportunistic infections in these animals can confound research and pose zoonotic risks.
- Understanding these infections is vital for primate health and research validity.
Purpose of the Study:
- To review common opportunistic infections in research nonhuman primates.
- To discuss clinical and pathological aspects of these infections.
- To outline strategies for risk reduction and surveillance.
Main Methods:
- Review of clinical and pathological data on opportunistic infections in nonhuman primates.
- Discussion of endogenous diseases (e.g., simian type D retroviruses, measles) and experimental models (e.g., simian immunodeficiency virus).
- Examination of surveillance programs and risk mitigation techniques.
Main Results:
- Common opportunistic infections in research primates are identified.
- Pathogenesis and clinical signs are detailed.
- The impact of these infections on research and zoonotic potential is highlighted.
Conclusions:
- Complete elimination of all infectious agents may be unfeasible.
- Microbial surveillance is essential for colony health and risk assessment.
- Quarantine, SPF animals, and environmental controls aid in risk reduction.
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