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Hyperbaric oxygen therapy improves myocardial diastolic function in diabetic patients.
Mustafa Aparci1, Ejder Kardesoglu, Selami Suleymanoglu
1Department of Cardiology, Gulhane Military Medical Academy, Haydarpasa Teaching Hospital.
The Tohoku Journal of Experimental Medicine
|March 8, 2008
Summary
Hyperbaric oxygen (HBO) therapy improved myocardial diastolic function in diabetic patients. Repetitive HBO sessions enhanced ventricular relaxation and diastolic filling dynamics, suggesting a potential therapeutic benefit for diabetic cardiovascular health.
Area of Science:
- Cardiology
- Diabetology
- Hyperbaric Medicine
Background:
- Myocardial diastolic dysfunction, a common issue in diabetes, impairs ventricular filling and can precede heart failure.
- Diabetic patients often undergo hyperbaric oxygen (HBO) therapy for complications like non-healing ulcers.
- HBO therapy is known to impact cardiovascular functions, necessitating investigation into its effects on diabetic diastolic function.
Purpose of the Study:
- To evaluate the impact of repetitive hyperbaric oxygen (HBO) therapy on myocardial diastolic function in diabetic patients.
- To assess changes in left and right ventricular diastolic filling dynamics following HBO treatment.
Main Methods:
- Thirty diabetic patients undergoing HBO therapy were enrolled.
- Myocardial diastolic function was assessed using pulsed wave Doppler echocardiography and tissue Doppler echocardiography.
- Evaluations were performed before the first and after the tenth HBO therapy session.
Main Results:
- HBO therapy significantly reduced E wave deceleration time, indicating improved left ventricular relaxation (286.1 +/- 65.8 msec vs 214.3 +/- 32.1 msec, p < 0.05).
- Favorable changes in right ventricular diastolic filling were observed, with a significant decrease in tricuspid valve E wave peak velocity (0.48 +/- 0.07 m/sec vs 0.46 +/- 0.09 m/sec, p < 0.05).
- Tissue Doppler parameters showed a trend towards improvement in ventricular relaxation, though not statistically significant.
Conclusions:
- Repetitive hyperbaric oxygen (HBO) therapy appears to enhance myocardial diastolic function in diabetic patients.
- HBO therapy may offer a beneficial effect on ventricular relaxation and diastolic filling dynamics in this population.
- Further research is warranted to confirm these findings and explore the clinical implications of HBO therapy for diabetic cardiovascular health.
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