Related Experiment Video
Updated: Jul 6, 2026

10:46
Doppler Optical Coherence Tomography of Retinal Circulation
Published on: September 18, 2012
Pulsatile ocular blood flow in healthy Koreans
Seung Kab Kim1, Byung Joo Cho, Samin Hong
1Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
Korean Journal of Ophthalmology : KJO
|March 8, 2008
Summary
This study established normal pulsatile ocular blood flow (POBF) reference ranges for healthy Koreans. POBF values are influenced by gender, blood pressure, pulse rate, and axial length.
Area of Science:
- Ophthalmology
- Ocular Physiology
- Medical Research
Background:
- Pulsatile ocular blood flow (POBF) is a key indicator of ocular health.
- Establishing normative data is crucial for diagnosing ocular vascular conditions.
- Previous studies have not comprehensively defined POBF ranges in the Korean population.
Purpose of the Study:
- To determine the normal reference range of pulsatile ocular blood flow (POBF) in healthy Korean subjects.
- To identify factors influencing POBF in this population.
- To provide essential data for clinical ophthalmological assessments.
Main Methods:
- A cross-sectional study involving 280 healthy Korean subjects.
- Measurement of best corrected visual acuity (BCVA), intraocular pressure (IOP), axial length, POBF, systemic blood pressure, and pulse rate.
- Statistical analysis including calculation of mean, standard deviation, percentiles, and multiple regression to identify influencing factors.
Main Results:
- Normal reference ranges for POBF were established for Korean men and women.
- Mean POBF values differed significantly between genders.
- POBF was significantly influenced by gender, mean blood pressure, pulse rate, and axial length.
Conclusions:
- Normal reference ranges for POBF in healthy Koreans were successfully defined.
- Gender, blood pressure, and axial length are significant determinants of POBF.
- These findings provide valuable normative data for clinical practice and research in ophthalmology.
Related Concept Videos
Blood Flow
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Autoregulation of Blood Flow
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Development of Blood Vessels
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...

