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A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
Published on: February 17, 2023
Reduced cytokine production by glycogen-elicited peritoneal cells from diabetic rats
Tatiana Carolina Alba-Loureiro1, Tania Cristina Pithon-Curi, Rui Curi
1Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, Brazil. tatica@icb.usp.br
Abstract:
IL-1beta, TNF-alpha, cytokine-induced neutrophil chemoattractant-2alpha/beta, and IL-10 measurements were performed in elicited peritoneal cells from control, diabetic, and insulin-treated diabetic rats. Production/liberation of these cytokines was decreased in elicited peritoneal cells from diabetic rats. These changes were abolished by insulin treatment of diabetic rats. The alterations observed might be involved in the impaired inflammatory response and high occurrence of apoptosis observed in neutrophils under diabetic states.