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Updated: Jul 6, 2026

Angiogenesis in the Ischemic Rat Lung
07:36

Angiogenesis in the Ischemic Rat Lung

Published on: February 8, 2013

A protocol for a lung neovascularization model in rodents.

Rosemary C Jones1, Diane Capen, Bodil Petersen

  • 1Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA. rcjones@partners.org

Nature Protocols
|March 8, 2008
PubMed
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This study introduces a rodent model protocol to analyze lung vascular remodeling after injury. It aims to identify key cells and molecular factors driving lung neovascularization for therapeutic insights.

Area of Science:

  • Cardiovascular Biology
  • Pulmonary Medicine
  • Regenerative Medicine

Background:

  • Vascular injury and repair are crucial for understanding human diseases.
  • Neovascularization research focuses on identifying critical cells and their roles in vascular assembly.
  • Effective therapeutic strategies require insights into cellular events during vascular repair.

Purpose of the Study:

  • To present a protocol for analyzing vessel and capillary remodeling in an injured lung using an in vivo rodent model.
  • To investigate the cellular and molecular mechanisms underlying lung neovascularization.
  • To facilitate the study of therapeutic strategies for vascular-related diseases.

Main Methods:

  • Development and implementation of a novel in vivo rodent model.

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  • Sequential analysis of vascular structure assembly stages.
  • Identification and characterization of relevant cell types involved in neovascularization.

    • Main Results:

    • The protocol allows for detailed examination of vessel and capillary remodeling in the injured lung.
    • It enables the study of sequential stages in vascular assembly.
    • Provides a framework for identifying key cellular players in lung neovascularization.

    Conclusions:

    • The proposed protocol offers a valuable tool for studying lung neovascularization in vivo.
    • Understanding cellular events in vascular repair can lead to improved therapeutic strategies.
    • Further research using this model can elucidate molecular determinants of lung neovascularization.