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Updated: Jul 6, 2026

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
Published on: December 22, 2023
MR-optical imaging of cardiovascular molecular targets
Matthias Nahrendorf1, David E Sosnovik, Ralph Weissleder
1Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, MA, USA. mnahrendorf@mgh.harvard.edu
Abstract:
Our understanding of the intricate inflammation biology underlying atherosclerosis is rapidly progressing. Molecular imaging strategies, harnessing this body of knowledge, have been developed to visualize some key cellular and molecular events in plaque evolution and vulnerability. Here, we discuss recent advances in magnetic resonance and fluorescence imaging of key biomarkers including adhesion molecules, inflammatory cells, and enzyme activity. We discuss strengths and limitations of respective imaging technologies, and comment on the potential of multi-modality imaging approaches.
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