Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intracerebroventricular phospho-tau immunotherapy alleviates cortical phospho-tau burden and motor phenotype in a neuron-specific P301S tauopathy mouse.

Experimental neurology·2025
Same author

"Limbic encephalitis with acute onset and Hu antibodies treated with rituximab: Paraneoplastic or non-paraneoplastic disorder?"

Clinical neurology and neurosurgery·2019
Same author

Clinical, Cytological, Histological and Immunohistochemical Features of Cutaneous Mast Cell Tumours in Ferrets (Mustela putorius furo).

Journal of comparative pathology·2016
Same author

ESGAR consensus statement on liver MR imaging and clinical use of liver-specific contrast agents.

European radiology·2015
Same author

iPad-based primary 2D reading of CT angiography examinations of patients with suspected acute gastrointestinal bleeding: preliminary experience.

The British journal of radiology·2015
Same author

Randomised controlled trial of doxorubicin-eluting beads vs conventional chemoembolisation for hepatocellular carcinoma.

British journal of cancer·2014

Related Experiment Video

Updated: Jul 6, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Diffusion-weighted imaging in patients with progressive multifocal leukoencephalopathy.

M Cosottini1, C Tavarelli, L Del Bono

  • 1Department of Neuroscience, University of Pisa, Via Roma n_67, Pisa, Italy, 56100. mircocosottini@libero.it

European Radiology
|March 8, 2008
PubMed
Summary

Diffusion-weighted imaging (DWI) shows that the central core of lesions in progressive multifocal leukoencephalopathy (PML) correlates with disease severity and duration. This advanced MRI technique offers prognostic information beyond conventional imaging for PML patients.

More Related Videos

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Related Experiment Videos

Last Updated: Jul 6, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Area of Science:

  • Neuroimaging
  • Neurology
  • Infectious Diseases

Background:

  • Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system caused by JC polyoma virus.
  • PML typically affects individuals with compromised T-cell immunity, such as those with HIV, malignancy, or on immunosuppressive therapy.
  • Currently, no established imaging methods correlate with the clinical status of PML patients.

Purpose of the Study:

  • To assess diffusion abnormalities in focal white matter lesions in PML patients using MRI.
  • To correlate lesion load, measured by conventional MRI and diffusion-weighted imaging (DWI), with clinical variables.
  • To investigate the prognostic value of DWI in characterizing PML lesions.

Main Methods:

  • Eight patients with biopsy or laboratory-confirmed PML were evaluated.
  • All patients underwent MRI, including fluid-attenuated inversion recovery (FLAIR) and DWI sequences.
  • Mean diffusivity (MD) maps quantified diffusion in white matter lesions; lesion load was calculated on FLAIR and DWI images, distinguishing central core and peripheral rim components.

Main Results:

  • PML lesions exhibited a central core with high mean diffusivity (MD) and a surrounding rim with lower MD.
  • Global lesion load on both FLAIR and DWI correlated significantly with disease duration and severity (Karnofsky scale, EDSS).
  • Central core lesion load on DWI strongly correlated with disease duration and severity, whereas the peripheral rim did not provide additional prognostic information.

Conclusions:

  • Global lesion load in PML correlates with disease duration and severity.
  • DWI can differentiate lesion components in PML, with a larger central core indicating a worse clinical status and longer disease duration.
  • DWI provides enhanced prognostic information in PML compared to conventional MRI by characterizing lesion components.