Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Can toxin warfare against fungal parasitism influence short-term Dolichospermum bloom dynamics? - A field observation.

Harmful algae·2020

Same author

Anatoxin-a producing Tychonema (Cyanobacteria) in European waterbodies.

Water research·2014

Same author

Toxin content and cytotoxicity of algal dietary supplements.

Toxicology and applied pharmacology·2012

Same author

The human relevant potency threshold: reducing uncertainty by human calibration of cumulative risk assessments.

Regulatory toxicology and pharmacology : RTP·2011

Same author

Quantitative assessment of aerosolized cyanobacterial toxins at two New Zealand lakes.

Journal of environmental monitoring : JEM·2011

Same author

The role of organic anion transporting polypeptides (OATPs/SLCOs) in the toxicity of different microcystin congeners in vitro: a comparison of primary human hepatocytes and OATP-transfected HEK293 cells.

Toxicology and applied pharmacology·2010

Search research articles

Related Experiment Video

Updated: Jul 6, 2026

The Forced Swim Test as a Model of Depressive-like Behavior

The Forced Swim Test as a Model of Depressive-like Behavior

Published on: March 2, 2015

Physiological endpoints for potential SSRI interactions in fish.

N Kreke¹, D R Dietrich

¹Environmental Toxicology, Department of Biology, University of Konstanz, Konstanz, Germany.

Critical Reviews in Toxicology

|March 8, 2008

Summary

Selective serotonin reuptake inhibitors (SSRIs) are environmental pollutants found in water. Their impact on fish is poorly understood due to limited knowledge of serotonin (5-HT) functions in aquatic species.

More Related Videos

Experimental Protocol for Examining Behavioral Response Profiles in Larval Fish: Application to the Neuro-stimulant Caffeine

Experimental Protocol for Examining Behavioral Response Profiles in Larval Fish: Application to the Neuro-stimulant Caffeine

Published on: July 24, 2018

Behavioral Approaches to Studying Innate Stress in Zebrafish

Behavioral Approaches to Studying Innate Stress in Zebrafish

Published on: May 1, 2019

Related Experiment Videos

Last Updated: Jul 6, 2026

The Forced Swim Test as a Model of Depressive-like Behavior

The Forced Swim Test as a Model of Depressive-like Behavior

Published on: March 2, 2015

Experimental Protocol for Examining Behavioral Response Profiles in Larval Fish: Application to the Neuro-stimulant Caffeine

Experimental Protocol for Examining Behavioral Response Profiles in Larval Fish: Application to the Neuro-stimulant Caffeine

Published on: July 24, 2018

Behavioral Approaches to Studying Innate Stress in Zebrafish

Behavioral Approaches to Studying Innate Stress in Zebrafish

Published on: May 1, 2019

Area of Science:

Environmental Science
Pharmacology
Aquatic Toxicology

Background:

Selective serotonin reuptake inhibitors (SSRIs) are increasingly detected in aquatic environments.
SSRIs are widely prescribed for depression and other neurological conditions, leading to global increases in their use.
Serotonin (5-HT), a neurotransmitter targeted by SSRIs, plays vital roles in both mammals and aquatic organisms, though its functions in fish are not fully elucidated.

Purpose of the Study:

To review the known functions of serotonin (5-HT) in fish physiology.
To characterize the potential impacts of chronic SSRI exposure on fish by comparing 5-HT functions in fish and mammals.
To evaluate the adequacy of current experimental approaches for environmental risk assessment of SSRIs in aquatic ecosystems.

Main Methods:

Literature review of serotonin (5-HT) functions in fish physiology.
Comparative analysis of 5-HT roles in mammals and fish.
Assessment of current methodologies for environmental risk assessment of pharmaceuticals.

Main Results:

The precise physiological roles of serotonin (5-HT) are not well-defined for many aquatic species.
Chronic SSRI exposure may significantly impact fish physiology due to the conserved nature of the 5-HT system.
Existing experimental methods may be insufficient for accurately assessing the environmental risks posed by SSRIs to aquatic life.

Conclusions:

Understanding serotonin (5-HT) functions in fish is crucial for evaluating SSRI ecotoxicity.
Current risk assessment strategies for environmental pharmaceuticals like SSRIs may need refinement.
Further research is needed to develop appropriate methods for assessing SSRI impacts on aquatic ecosystems.