Related Experiment Video

Updated: Jul 6, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Genetic changes and DNA damage responses in the prostate

Taija M Kiviharju-Af Hällström1, Marikki Laiho

  • 1Molecular Cancer Biology Program, Biomedicum Helsinki and Haartman Institute, University of Helsinki, Helsinki, Finland.

The Prostate
|March 8, 2008
PubMed

Insights

Genomic DNA integrity is crucial for preventing cancer. This review explores how DNA damage response defects in prostate cells contribute to prostate cancer development.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Genomic DNA integrity is constantly challenged by metabolic byproducts and external factors.
  • Cellular responses to DNA damage include cell cycle arrest, repair, apoptosis, and senescence.
  • Alterations in DNA damage response genes are linked to cancer susceptibility and sporadic tumors.

Purpose of the Study:

  • To review the role of prostatic epithelial cells in prostate tumorigenesis.
  • To highlight molecular alterations common in prostate cancer.
  • To discuss DNA damage responses in human prostate cells and tissues.

Main Methods:

  • Review of existing literature on DNA damage response pathways.
  • Analysis of molecular changes in prostate cancer.
  • Examination of DNA damage responses in primary human prostate epithelial cells and tissues.

Main Results:

  • Prostatic epithelial cells play a significant role in prostate tumorigenesis.
  • Common molecular changes in prostate cancer involve DNA damage response pathways.
  • Evidence suggests alterations in key DNA damage checkpoint molecules in human prostate cells and tissues.

Conclusions:

  • Defects in DNA damage response pathways are implicated in prostate cancer.
  • Maintaining genomic integrity is a critical barrier against cancer development.
  • Further research into these pathways may offer new therapeutic strategies for prostate cancer.

More Related Videos

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis07:42

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Published on: November 26, 2015

Related Concept Videos

Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...