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Updated: Jul 6, 2026

Porous Silicon Microparticles for Delivery of siRNA Therapeutics
Published on: January 15, 2015
Hollow silica nanocontainers as drug delivery vehicles
Jaemoon Yang1, Jaewon Lee, Jinyoung Kang
1Department of Chemical Engineering, Yonsei University, Seoul 120-749, Korea, Graduate Program for Nanomedical Science, Yonsei University, Seoul 120-752, Korea.
Abstract:
Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe(3)O(4) nanocrystals, as templates. The core cavity was obtained by removal of Fe(3)O(4) phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.
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