Related Experiment Video
Updated: Jul 6, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
The effect of anticholinergic agents on gastro-oesophageal reflux and related disorders
Eva M van Soest1, Jeanne P Dieleman, Ernst J Kuipers
1Erasmus University Medical Center, Department of Gastroenterology and Hepatology, Postbus 2040, 3000 CA Rotterdam, The Netherlands. e.vansoest@erasmusmc.nl
Abstract:
The most important risk factor of oesophageal adenocarcinoma is gastro-oesophageal reflux disease. Gastro-oesophageal reflux disease is in itself a common disorder, giving bothersome symptoms. In daily clinical practice, anticholinergic drugs are believed to increase the risk of gastro-oesophageal reflux through effects on the lower oesophageal sphincter. In this review we discuss the available literature on the potential association between the use of drugs with anticholinergic properties and the risk of gastro-oesophageal reflux-related disorders.
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