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The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
Mycobacterium ulcerans disease, Peru
Humberto Guerra1, Juan Carlos Palomino, Eduardo Falconí
1Universidad Peruana Cayetano Heredia, Lima, Perú.
Emerging Infectious Diseases
|March 8, 2008
Summary
Buruli ulcer (BU) is an infectious skin disease found in Peru, though seemingly rare. Diverse treatments, including WHO-recommended drugs and surgery, proved effective for moderate cases in this study.
Area of Science:
- Infectious Diseases
- Dermatology
- Tropical Medicine
Background:
- Buruli ulcer (BU) is a neglected tropical disease caused by Mycobacterium ulcerans.
- It primarily affects the skin and can lead to significant disfigurement and disability.
- BU is endemic in several tropical and subtropical regions worldwide.
Purpose of the Study:
- To report cases of Buruli ulcer in Peru over a 10-year period.
- To describe patient demographics, lesion characteristics, and treatment outcomes.
- To highlight the need for increased awareness and diagnostic capacity for BU in Peru.
Main Methods:
- Retrospective review of eight adult patients diagnosed with Buruli ulcer between 2000 and 2010.
- Diagnosis confirmed by at least two methods; Mycobacterium ulcerans culture attempts were unsuccessful.
- Clinical data, treatment regimens, and outcomes were analyzed.
Main Results:
- Eight adult patients (18-58 years) presented with 1-5 Buruli ulcer lesions, predominantly on lower extremities.
- Five patients originated from jungle areas, and three from swampy coastal regions of Peru.
- All five patients with available follow-up showed moderate disease and responded well to various treatments, including WHO-recommended antimicrobials and surgery.
Conclusions:
- Buruli ulcer is present in Peru, though its prevalence appears low.
- Effective treatment outcomes were observed with diverse therapeutic approaches.
- Improved public education and healthcare worker training are crucial for accurate diagnosis and management of Buruli ulcer in Peru.
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