Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pernio (chilblains).

Amjad Almahameed1, Duane S Pinto

  • 1RPVI Division of Cardiology, The Cardiovascular Institute at Beth Israel Deaconess Medical Center, Harvard Medical School, One Deaconess Road, Boston, MA 02115, USA. aalmaham@bidmc.harvard.edu

Current Treatment Options in Cardiovascular Medicine
|March 8, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electrophysiological observations during and after transcatheter aortic valve replacement.

Heart rhythm·2026
Same author

Mechanisms Underlying Alterations in Cardiac Conduction After Transcatheter Aortic Valve Replacement.

JAMA cardiology·2025
Same author

Transcatheter aortic valve implantation with the Trilogy valve for symptomatic native aortic regurgitation (ALIGN-AR): a pivotal, multicentre, single-arm, investigational device exemption study.

Lancet (London, England)·2025
Same author

The CLTI Paradigm Shift: Implications for Clinical Trial Design and Endpoints in Endovascular Management of Infrapopliteal Disease.

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists·2025
Same author

Predictors of pacemaker implantation in aortic regurgitation patients treated with a dedicated transcatheter heart valve.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·2025
Same author

High-Output Mechanical Circulatory Support in Left Main Interventions: The Magenta Elevate High-Risk PCI First-in-Human Study.

JACC. Cardiovascular interventions·2024
Same journal

An Update on the Role of Renal Artery Denervation in the Treatment of Hypertension.

Current treatment options in cardiovascular medicine·2026
Same journal

Advancements and Challenges in Contemporizing Care for Adult Patients with Congenital Heart Disease and Advanced Heart Failure: An Update on Application of Modern Heart Failure Technologies.

Current treatment options in cardiovascular medicine·2026
Same journal

Evolving Decongestion Strategies in the Management of Acute Heart Failure.

Current treatment options in cardiovascular medicine·2025
Same journal

Advanced Electroanatomic Mapping: Current and Emerging Approaches.

Current treatment options in cardiovascular medicine·2025
Same journal

Metabolic Reprogramming in Heart Failure: From Energy Starvation to Therapeutic Targets.

Current treatment options in cardiovascular medicine·2025
Same journal

Drug-Coated Balloons for Coronary Artery Disease: From Theory to Practice.

Current treatment options in cardiovascular medicine·2025
See all related articles

Pernio, a cold-induced vasospastic disorder, affects exposed skin. Nifedipine, a calcium channel blocker, can accelerate healing and prevent pernio recurrence.

Area of Science:

  • Dermatology
  • Vascular Medicine
  • Immunology

Background:

  • Pernio is a vasospastic condition affecting skin exposed to cold, damp conditions.
  • It can be idiopathic or linked to systemic diseases like cryopathies and lupus erythematosus.
  • Symptoms range from acute, appearing hours after exposure, to chronic, persisting long after cold weather ends.

Purpose of the Study:

  • To summarize the clinical features, pathophysiology, diagnosis, and treatment of pernio.
  • To highlight the role of nifedipine in managing pernio.

Main Methods:

  • Clinical diagnosis based on characteristic features.
  • Skin biopsy may be used to rule out other conditions.
  • Treatment focuses on rewarming and cold avoidance, with pharmacological interventions explored.

Related Experiment Videos

Main Results:

  • Pernio diagnosis relies on clinical presentation; histopathology is not diagnostic but aids in differential diagnosis.
  • Potential sequelae include secondary infection, skin depigmentation, and scarring.
  • Rewarming and cold avoidance are primary management strategies.

Conclusions:

  • Pernio is a clinical diagnosis with complex pathophysiology.
  • Nifedipine, a dihydropyridine calcium channel blocker, demonstrates efficacy in promoting healing and preventing recurrence.
  • Comprehensive management involves environmental control and targeted medical therapy.