Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Signal transduction and gene control.

M Karin1

  • 1Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla 92093.

Current Opinion in Cell Biology
|June 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling.

Oncogene·2015
Same author

Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation.

Cell death and differentiation·2015
Same author

IKKβ in postnatal perichondrium remotely controls endochondral ossification of the growth plate through downregulation of MCP-5.

Cell death and differentiation·2014
Same author

Choline kinase inhibition in rheumatoid arthritis.

Annals of the rheumatic diseases·2014
Same author

Roles of tumor suppressors in regulating tumor-associated inflammation.

Cell death and differentiation·2014
Same author

Gene amplification in yeast: CUP1 copy number regulates copper resistance.

Current genetics·2013

Extracellular signals control gene expression through protein phosphorylation and interactions. These processes alter transcription factor activity, influencing DNA binding and cellular responses.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Gene Regulation

Background:

  • Extracellular signals initiate cellular responses via signal transduction pathways.
  • Transcription factor activity is a key regulator of gene expression.
  • Post-translational modifications, like phosphorylation, are crucial for modulating protein function.

Purpose of the Study:

  • To elucidate the mechanisms by which extracellular signals modulate transcription factor activity.
  • To highlight the role of phosphorylation and protein-protein interactions in signal transduction.
  • To understand the impact of these modifications on gene expression regulation.

Main Methods:

  • Analysis of signal transduction cascades.
  • Investigation of transcription factor phosphorylation.

Related Experiment Videos

  • Study of protein-protein interactions in nuclear signaling.

    • Main Results:

    • Phosphorylation significantly alters transcription factor activity at multiple levels.
    • Modulation of intracellular localization, DNA-binding, and transcriptional activation domains by phosphorylation.
    • Protein-protein interactions mediate crosstalk between signaling pathways at the nuclear level.

    Conclusions:

    • Phosphorylation is a primary mechanism for extracellular signal-mediated regulation of transcription factors.
    • Nuclear protein interactions play a vital role in integrating signaling pathways.
    • These molecular events are fundamental to cellular responses and gene expression control.