Synthesis of bis-diosgenin pyrazine dimers: new cephalostatin analogs
Khaled Q Shawakfeh1, Naim H Al-Said, Raed M Al-Zoubi
1Department of Applied Chemical Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan. shawakfa@just.edu
Steroids
|March 8, 2008
Abstract:
A convenient synthesis for bis-diosgenin pyrazine dimers, cephalostatin analogues is reported. These symmetrical dimeric steroid-pyrazines were obtained by the classical condensation of alpha-amino ketones, the most efficient method for pyrazine ring construction.
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