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Related Experiment Video

Updated: Jul 6, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

The methylome: approaches for global DNA methylation profiling.

Stephan Beck1, Vardhman K Rakyan

  • 1UCL Cancer Institute, University College London, London WC1E 6BT, UK. s.beck@ucl.ac.uk

Trends in Genetics : TIG
|March 8, 2008
PubMed
Summary

High-resolution DNA methylation profiling, or methylome mapping, is now achievable in large genomes. This breakthrough enables comprehensive analysis of DNA methylation in human development and disease.

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Area of Science:

  • Epigenetics and Genomics

Background:

  • DNA methylation is crucial for genome function in health and disease.
  • The first high-resolution methylome of Arabidopsis thaliana has been determined.
  • This achievement paves the way for mapping large mammalian genomes.

Purpose of the Study:

  • To review technologies for generating the first mammalian methylome.
  • To enable comprehensive DNA methylation profiling in various cell types.
  • To understand DNA methylation in development, disease, and environmental contexts.

Main Methods:

  • Review of current and emerging DNA methylation profiling technologies.
  • Focus on technologies capable of high-resolution methylome mapping.
  • Consideration of scalability for large mammalian genomes.

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Targeted DNA Methylation Analysis by Next-generation Sequencing
08:38

Targeted DNA Methylation Analysis by Next-generation Sequencing

Published on: February 24, 2015

DNA Methylation: Bisulphite Modification and Analysis
12:34

DNA Methylation: Bisulphite Modification and Analysis

Published on: October 21, 2011

Related Experiment Videos

Last Updated: Jul 6, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Targeted DNA Methylation Analysis by Next-generation Sequencing
08:38

Targeted DNA Methylation Analysis by Next-generation Sequencing

Published on: February 24, 2015

DNA Methylation: Bisulphite Modification and Analysis
12:34

DNA Methylation: Bisulphite Modification and Analysis

Published on: October 21, 2011

Main Results:

  • The Arabidopsis thaliana methylome demonstrated the feasibility of high-resolution mapping.
  • Mammalian methylomes are now within reach due to technological advancements.
  • Emerging technologies promise comprehensive profiling across cell types.

Conclusions:

  • Technological progress has made mammalian methylome sequencing attainable.
  • Comprehensive DNA methylation analysis will advance understanding of biology and disease.
  • Future research will focus on profiling diverse cell types and conditions.