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Updated: Jul 6, 2026

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
Published on: July 16, 2014
[Chronic sciatic pain caused by sciatic nerve schwannoma]
C Blanchard1, P Dam-Hieu, F Zagnoli
1Service de neurologie, hôpital d'instruction des armées Clermont-Tonnerre, rue du Colonel-Fontferrier, 29240 Brest Naval, France. christian.blanchard@dbmail.com
Abstract:
Schwannomas are tumors with slowly progressive symptoms, more often painful than associated with neurologic deficits. Involvement of the sciatic nerve mimics chronic sciatic pain due to a herniated disk. If there is no lumbar pain and lumbar MRI is normal, the sciatic nerve must be clinically and radiologically examined all along its course. We report a patient with chronic sciatica in whom physical examination revealed a painful mass with a Tinel sign in her back thigh. MRI showed a multilobular mass along the sciatic nerve. Surgery of this plexiform schwannoma allowed a complete relief from pain.
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