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[Cardiac rhythm variability during active orthostatic test in patients with arterial hypertension]

L I Gapon, T V Sereda, N N Korzhova

    Klinicheskaia Meditsina
    |March 11, 2008
    PubMed

    Insights

    This study assessed cardiac rhythm variability (CRV) during an active orthostatic test (AOT) in arterial hypertension (AH) patients. Results show autonomic nervous system imbalances in AH patients, with preserved adaptive abilities.

    Area of Science:

    • Cardiology
    • Physiology
    • Autonomic Nervous System Research

    Background:

    • Arterial hypertension (AH) is associated with cardiovascular risks.
    • Autonomic nervous system (ANS) dysfunction is implicated in AH.
    • Assessing ANS function during orthostatic stress is crucial for understanding cardiovascular regulation.

    Purpose of the Study:

    • To evaluate cardiac rhythm variability (CRV) during an active orthostatic test (AOT) in patients with AH.
    • To compare CRV parameters between AH patients and healthy controls.
    • To investigate ANS regulation of cardiac rhythm in AH.

    Main Methods:

    • Recruited 52 patients with AH and 32 healthy controls.
    • Conducted 5-minute CRV recordings in supine and AOT positions.
    • Analyzed temporary and spectral CRV parameters.

    Main Results:

    • Significant differences in temporary CRV parameters were observed during AOT in both groups.
    • AH patients showed greater deviations in optimal variability compared to controls.
    • Spectral analysis revealed increased sympathetic influence and decreased parasympathetic activity in AH patients.

    Conclusions:

    • Patients with AH exhibit a disbalance in vegetative regulation of cardiac rhythm.
    • Both temporary and spectral analyses indicate ANS dysregulation in AH.
    • Despite ANS imbalances, adaptive capacities of cardiac rhythm regulation mechanisms were preserved in AH patients during AOT.

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