Related Experiment Video
Updated: Jul 6, 2026

Quantification of Orofacial Phenotypes in Xenopus
Published on: November 6, 2014
[Heridity of non-syndromal orofacial clefts]
H Van Esch1, A Verdonck, C E L Carels
1Centrum voor Menselijke Erfelijkheid van het Universitair Ziekenhuis Leuven in België. hilde.vanesch@uz.kuleuven.ac.be
Abstract:
Non-syndromal orofacial clefts are congenital anomalies with a high incidence of heterogeneous origin. The condition is usually multifactorially determined, caused by interaction between multiple genetic and environmental factors. So far, only a few causal factors have been identified. Even in genetically identical individuals like monozygotic twins, the orofacial cleft is usually not fully concordant. As an illustration of non-syndromal orofacial clefts, monozygotic twin brothers with orofacial clefts which are not fully concordant are presented.
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