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Sleep-disordered breathing, cognitive functioning, and adherence in heart failure: linked through pathology?
Robin J Trupp1, Elizabeth J Corwin
1Ohio State University, College of Nursing, Columbus, OH, USA. trupp3@osu.edu
Progress in Cardiovascular Nursing
|March 11, 2008
Summary
Heart failure and sleep-disordered breathing worsen cognitive function and adherence due to shared neurohormonal pathways. Addressing both conditions may improve patient outcomes and treatment compliance.
Area of Science:
- Cardiology
- Sleep Medicine
- Neuroscience
Background:
- Heart failure (HF) involves chronic neurohormonal activation.
- Sleep-disordered breathing (SDB) is a less recognized neurohormonal disorder.
- Both HF and SDB share symptoms like fatigue and cognitive impairment.
Purpose of the Study:
- To explore the synergistic impact of co-existing HF and SDB on patient outcomes.
- To investigate the neurohormonal mechanisms linking HF and SDB.
- To understand the effect on cognitive function, decision-making, and treatment adherence.
Main Methods:
- Review of existing literature on HF and SDB.
- Analysis of neurohormonal pathways implicated in both conditions.
- Examination of the combined effects on cognitive function and adherence.
Main Results:
- Repetitive hypoxia-reoxygenation in SDB causes sympathetic activation.
- Co-occurrence of HF and SDB exacerbates cognitive deficits.
- Neurohormonal synergism between HF and SDB may underlie poor treatment adherence.
Conclusions:
- Combined HF and SDB present significant challenges for cognitive function and adherence.
- Understanding the neurohormonal interplay is crucial for managing patients with both conditions.
- Targeting the synergistic effects could improve therapeutic adherence and patient outcomes.
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